Discovered in the 1930's and extracted in 1957, Alpha-Lipoic Acid is a unique free-radical protector for our cells because it is the only such nutrient which is both fat and water-soluble. Alpha-Lipoic Acid has excellent bioavailability and can easily travel across cell membranes to fight free radicals both inside and outside the cell. Once inside the cell, Alpha Lipoic Acid is broken down to dihydrophilic acid, an even more potent neutralizer of free radicals.
Of particular importance to antioxidant researchers is Alpha-Lipoic Acids apparent ability to regenerate and actually prolong antioxidant activity of such important nutrients as Vitamins C, E and glutathione; offering enhanced protection and healing. In fact, many of the beneficial effects of Alpha-Lipoic Acid may be due to its ability to regenerate glutathione, a potent amino acid antioxidant. This amino acid is a powerful immune enhancer, liver protector, and heavy metal detoxifier. Because it is a sulphur compound, Alpha-Lipoic Acid can bind and help eliminate heavy metals such as copper, iron, mercury and cadmium; risk factors for a wide range of degenerative disease. In German studies of Type II diabetes (NIDDM), Alpha-Lipoic Acid has shown promise as well as in cataract studies at the University of California at Berkeley and in cardiovascular studies concerned with LDL (bad cholesterol) levels.
Although there have been hundreds of studies over the last 40+ years revealing how Alpha-Lipoic Acid energized metabolism, the new excitement about this vitamin-like substance can be seen in the many recent studies focusing on how it improves the physique, combats free radicals, protects our genetic material, helps the body with healing, slows aging, helps protect against heart disease, cancer and many other diseases, according to Richard A. Passwater, Ph-D., In Lipoic Acid: The Metabolic Antioxidant.
"Lipoic acid has also been used for decades to protect the liver and to detoxify the body of heavy metal pollutants, such as excessive iron, copper and toxic metals such as cadmium, lead and mercury," Passwater continues. One of the exciting recent developments is that Alpha-Lipoic Acid appears to help slow the progression of HIV-infection to clinical AIDS."
It appears that Alpha-Lipoic Acid, alone or together with vitamin E, is an effective treatment for radiation exposure, lessening indices of oxidative damage and normalizing organ function, according to Lester Packer, Ph.D., et al. in Free Radical Biology and Medicine 1995. This therapy has been effective in treating children living in areas affected by the Chernobyl accident in the former Soviet Union.